Gene

cdh2

ID
ZDB-GENE-990415-171
Name
cadherin 2, type 1, N-cadherin (neuronal)
Symbol
cdh2 Nomenclature History
Previous Names
  • bib
  • glass onion (1)
  • glo (1)
  • labyrinth (1)
  • lyr (1)
  • n-cadherin (1)
  • ncad
  • neural cadherin
  • pac (1)
  • parachute (1)
  • wu:fb47h04
  • zncad
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable beta-catenin binding activity; cadherin binding activity; and calcium ion binding activity. Involved in cell-cell adhesion and neural tube formation. Acts upstream of or within several processes, including axial mesoderm structural organization; embryonic morphogenesis; and nervous system development. Located in cell-cell junction; perinuclear region of cytoplasm; and presynaptic membrane. Part of catenin complex. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
61 figures from 40 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
93 figures from 32 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdh2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agenesis of corpus callosum, cardiac, ocular, and genital syndrome Alliance Agenesis of corpus callosum, cardiac, ocular, and genital syndrome 618929
arrhythmogenic right ventricular dysplasia 14 Alliance Arrhythmogenic right ventricular dysplasia 14 618920
?Attention deficit-hyperactivity disorder 8 619957
1 - 3 of 3
Associated With cdh2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, Y-type LIR-motif
Domain IPR002126 Cadherin-like
Domain IPR014868 Cadherin prodomain
Family IPR039808 Cadherin
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length Cadherin Cadherin conserved site Cadherin-like Cadherin-like superfamily Cadherin prodomain Cadherin, Y-type LIR-motif Catenin binding domain superfamily
UniProtKB:Q90275 InterPro 893
UniProtKB:Q1L8K3 InterPro 893
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cdh2-201 (1)
Ensembl
Ensembl 4,853 nt
ZFIN BLAST
mRNA cdh2-202 (1)
Ensembl
Ensembl 2,429 nt
ZFIN BLAST
mRNA cdh2-203 (1)
Ensembl
Ensembl 2,809 nt
ZFIN BLAST
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pan-Cadherin polyclonal Rabbit
  • IHC
  • WB
 Sigma-Aldrich
29
Ab4-cdh2 polyclonal Rabbit
  • WB
 2
Ab1-cdh2 polyclonal Rabbit
  • IHC
  • WB
 9
1 - 3 of 3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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